| New York City, NY (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 5454 | $202 | Delta |
| Chicago, IL → Tampa, FL (Metropolitan Area) | 2776 | $215 | Southwest |
| Tampa, FL (Metropolitan Area) → Washington, DC (Metropolitan Area) | 2615 | $250 | Southwest |
| Boston, MA (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 2330 | $237 | Delta |
| Philadelphia, PA → Tampa, FL (Metropolitan Area) | 2089 | $225 | American |
| Detroit, MI → Tampa, FL (Metropolitan Area) | 2006 | $216 | Delta |
| Dallas/Fort Worth, TX → Tampa, FL (Metropolitan Area) | 1574 | $242 | American |
| Denver, CO → Tampa, FL (Metropolitan Area) | 1561 | $243 | United |
| Minneapolis/St. Paul, MN → Tampa, FL (Metropolitan Area) | 1557 | $248 | Delta |
| Atlanta, GA (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 1543 | $224 | Delta |
| Los Angeles, CA (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 1157 | $345 | Delta |
| Cleveland, OH (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 1095 | $161 | Frontier |
| Nashville, TN → Tampa, FL (Metropolitan Area) | 1063 | $207 | Southwest |
| Houston, TX → Tampa, FL (Metropolitan Area) | 872 | $261 | United |
| Indianapolis, IN → Tampa, FL (Metropolitan Area) | 868 | $224 | Southwest |
| Las Vegas, NV → Tampa, FL (Metropolitan Area) | 856 | $324 | Southwest |
| Cincinnati, OH → Tampa, FL (Metropolitan Area) | 824 | $177 | Frontier |
| Phoenix, AZ → Tampa, FL (Metropolitan Area) | 798 | $364 | American |
| Miami, FL (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 788 | $212 | American |
| Raleigh/Durham, NC → Tampa, FL (Metropolitan Area) | 770 | $192 | Delta |
| Pittsburgh, PA → Tampa, FL (Metropolitan Area) | 708 | $224 | Southwest |
| San Francisco, CA (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 670 | $359 | United |
| Charlotte, NC → Tampa, FL (Metropolitan Area) | 669 | $280 | American |
| Hartford, CT → Tampa, FL (Metropolitan Area) | 651 | $199 | JetBlue |
| Grand Rapids, MI → Tampa, FL (Metropolitan Area) | 630 | $158 | Allegiant |
| Columbus, OH → Tampa, FL (Metropolitan Area) | 619 | $234 | Southwest |
| New Orleans, LA → Tampa, FL (Metropolitan Area) | 564 | $192 | Southwest |
| Seattle, WA → Tampa, FL (Metropolitan Area) | 560 | $320 | Alaska |
| Austin, TX → Tampa, FL (Metropolitan Area) | 556 | $261 | Southwest |
| St. Louis, MO → Tampa, FL (Metropolitan Area) | 546 | $267 | Southwest |
| Kansas City, MO → Tampa, FL (Metropolitan Area) | 524 | $243 | Southwest |
| San Diego, CA → Tampa, FL (Metropolitan Area) | 519 | $270 | Alaska |
| Buffalo, NY → Tampa, FL (Metropolitan Area) | 511 | $228 | Southwest |
| Salt Lake City, UT → Tampa, FL (Metropolitan Area) | 480 | $374 | Delta |
| Milwaukee, WI → Tampa, FL (Metropolitan Area) | 407 | $269 | Southwest |
| Rochester, NY → Tampa, FL (Metropolitan Area) | 358 | $186 | Southwest |
| Syracuse, NY → Tampa, FL (Metropolitan Area) | 351 | $184 | Allegiant |
| Richmond, VA → Tampa, FL (Metropolitan Area) | 349 | $181 | Breeze |
| Albany, NY → Tampa, FL (Metropolitan Area) | 347 | $232 | Southwest |
| Louisville, KY → Tampa, FL (Metropolitan Area) | 335 | $218 | Southwest |
| Norfolk, VA (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 316 | $177 | Breeze |
| San Antonio, TX → Tampa, FL (Metropolitan Area) | 292 | $278 | Southwest |
| Knoxville, TN → Tampa, FL (Metropolitan Area) | 281 | $136 | Allegiant |
| Flint, MI → Tampa, FL (Metropolitan Area) | 269 | $129 | Allegiant |
| Charleston, SC → Tampa, FL (Metropolitan Area) | 264 | $172 | Breeze |
| New Haven, CT → Tampa, FL (Metropolitan Area) | 261 | $114 | XP |
| Birmingham, AL → Tampa, FL (Metropolitan Area) | 234 | $264 | Southwest |
| Allentown/Bethlehem/Easton, PA → Tampa, FL (Metropolitan Area) | 229 | $136 | Allegiant |
| Omaha, NE → Tampa, FL (Metropolitan Area) | 223 | $230 | Allegiant |
| Des Moines, IA → Tampa, FL (Metropolitan Area) | 221 | $202 | Allegiant |
| Memphis, TN → Tampa, FL (Metropolitan Area) | 215 | $214 | Breeze |
| Portland, OR → Tampa, FL (Metropolitan Area) | 215 | $320 | Delta |
| Atlantic City, NJ → Tampa, FL (Metropolitan Area) | 214 | $107 | Spirit |
| Bangor, ME → Tampa, FL (Metropolitan Area) | 213 | $131 | Allegiant |