| Los Angeles, CA (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 15083 | $201 | Southwest |
| New York City, NY (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 7028 | $518 | United |
| Las Vegas, NV → San Francisco, CA (Metropolitan Area) | 5452 | $201 | Southwest |
| San Diego, CA → San Francisco, CA (Metropolitan Area) | 5379 | $186 | Southwest |
| San Francisco, CA (Metropolitan Area) → Seattle, WA | 4696 | $225 | Alaska |
| Phoenix, AZ → San Francisco, CA (Metropolitan Area) | 3829 | $217 | Southwest |
| Chicago, IL → San Francisco, CA (Metropolitan Area) | 2728 | $328 | United |
| Denver, CO → San Francisco, CA (Metropolitan Area) | 2675 | $261 | United |
| San Francisco, CA (Metropolitan Area) → Washington, DC (Metropolitan Area) | 2605 | $411 | United |
| Dallas/Fort Worth, TX → San Francisco, CA (Metropolitan Area) | 2474 | $292 | American |
| Boston, MA (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 2461 | $407 | United |
| Portland, OR → San Francisco, CA (Metropolitan Area) | 2225 | $203 | Alaska |
| Miami, FL (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 2122 | $398 | United |
| Austin, TX → San Francisco, CA (Metropolitan Area) | 2039 | $289 | United |
| Salt Lake City, UT → San Francisco, CA (Metropolitan Area) | 1851 | $253 | Delta |
| Houston, TX → San Francisco, CA (Metropolitan Area) | 1641 | $337 | United |
| Atlanta, GA (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 1536 | $405 | Delta |
| Orlando, FL → San Francisco, CA (Metropolitan Area) | 1324 | $361 | United |
| Palm Springs, CA → San Francisco, CA (Metropolitan Area) | 1119 | $229 | United |
| Philadelphia, PA → San Francisco, CA (Metropolitan Area) | 1032 | $368 | American |
| Minneapolis/St. Paul, MN → San Francisco, CA (Metropolitan Area) | 924 | $344 | Delta |
| Detroit, MI → San Francisco, CA (Metropolitan Area) | 803 | $426 | Delta |
| New Orleans, LA → San Francisco, CA (Metropolitan Area) | 694 | $315 | United |
| Nashville, TN → San Francisco, CA (Metropolitan Area) | 671 | $324 | United |
| San Francisco, CA (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 670 | $359 | United |
| Raleigh/Durham, NC → San Francisco, CA (Metropolitan Area) | 653 | $374 | United |
| Boise, ID → San Francisco, CA (Metropolitan Area) | 602 | $203 | Southwest |
| Charlotte, NC → San Francisco, CA (Metropolitan Area) | 495 | $432 | American |
| Indianapolis, IN → San Francisco, CA (Metropolitan Area) | 413 | $324 | United |
| Albuquerque, NM → San Francisco, CA (Metropolitan Area) | 401 | $278 | Southwest |
| San Francisco, CA (Metropolitan Area) → Tucson, AZ | 392 | $266 | United |
| San Francisco, CA (Metropolitan Area) → St. Louis, MO | 389 | $376 | Southwest |
| San Francisco, CA (Metropolitan Area) → Spokane, WA | 383 | $204 | Southwest |
| San Antonio, TX → San Francisco, CA (Metropolitan Area) | 378 | $300 | Southwest |
| Reno, NV → San Francisco, CA (Metropolitan Area) | 373 | $251 | United |
| Pittsburgh, PA → San Francisco, CA (Metropolitan Area) | 369 | $337 | United |
| Kansas City, MO → San Francisco, CA (Metropolitan Area) | 354 | $327 | Southwest |
| Cleveland, OH (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 335 | $351 | United |
| San Francisco, CA (Metropolitan Area) → Santa Barbara, CA | 335 | $236 | United |
| Columbus, OH → San Francisco, CA (Metropolitan Area) | 290 | $341 | Southwest |
| Eugene, OR → San Francisco, CA (Metropolitan Area) | 258 | $220 | United |
| Bozeman, MT → San Francisco, CA (Metropolitan Area) | 228 | $309 | United |
| Cincinnati, OH → San Francisco, CA (Metropolitan Area) | 226 | $384 | Delta |
| Bend/Redmond, OR → San Francisco, CA (Metropolitan Area) | 218 | $211 | United |