| Los Angeles, CA (Metropolitan Area) → San Antonio, TX | 928 | $294 | Southwest |
| Las Vegas, NV → San Antonio, TX | 924 | $262 | Southwest |
| Dallas/Fort Worth, TX → San Antonio, TX | 892 | $258 | Southwest |
| San Antonio, TX → Washington, DC (Metropolitan Area) | 890 | $303 | United |
| Denver, CO → San Antonio, TX | 821 | $210 | Southwest |
| New York City, NY (Metropolitan Area) → San Antonio, TX | 769 | $313 | United |
| Orlando, FL → San Antonio, TX | 710 | $232 | Southwest |
| Phoenix, AZ → San Antonio, TX | 645 | $256 | Southwest |
| Chicago, IL → San Antonio, TX | 596 | $291 | United |
| Atlanta, GA (Metropolitan Area) → San Antonio, TX | 587 | $302 | Delta |
| Miami, FL (Metropolitan Area) → San Antonio, TX | 446 | $258 | American |
| San Antonio, TX → Seattle, WA | 388 | $255 | Alaska |
| San Antonio, TX → San Francisco, CA (Metropolitan Area) | 378 | $300 | Southwest |
| San Antonio, TX → San Diego, CA | 345 | $290 | Southwest |
| Boston, MA (Metropolitan Area) → San Antonio, TX | 315 | $334 | Delta |
| Nashville, TN → San Antonio, TX | 305 | $293 | Southwest |
| Salt Lake City, UT → San Antonio, TX | 298 | $354 | Delta |
| San Antonio, TX → Tampa, FL (Metropolitan Area) | 292 | $278 | Southwest |
| Detroit, MI → San Antonio, TX | 284 | $366 | Delta |
| El Paso, TX → San Antonio, TX | 279 | $267 | Southwest |
| Minneapolis/St. Paul, MN → San Antonio, TX | 271 | $369 | Delta |
| Charlotte, NC → San Antonio, TX | 269 | $306 | American |
| San Antonio, TX → St. Louis, MO | 231 | $288 | Southwest |
| New Orleans, LA → San Antonio, TX | 215 | $251 | Southwest |