| New York City, NY (Metropolitan Area) → Raleigh/Durham, NC | 2912 | $164 | Delta |
| Miami, FL (Metropolitan Area) → Raleigh/Durham, NC | 1619 | $191 | American |
| Orlando, FL → Raleigh/Durham, NC | 1538 | $177 | Delta |
| Boston, MA (Metropolitan Area) → Raleigh/Durham, NC | 1296 | $190 | Delta |
| Dallas/Fort Worth, TX → Raleigh/Durham, NC | 912 | $266 | American |
| Raleigh/Durham, NC → Washington, DC (Metropolitan Area) | 877 | $231 | American |
| Atlanta, GA (Metropolitan Area) → Raleigh/Durham, NC | 875 | $239 | Delta |
| Chicago, IL → Raleigh/Durham, NC | 849 | $244 | United |
| Los Angeles, CA (Metropolitan Area) → Raleigh/Durham, NC | 807 | $360 | Delta |
| Raleigh/Durham, NC → Tampa, FL (Metropolitan Area) | 770 | $192 | Delta |
| Denver, CO → Raleigh/Durham, NC | 682 | $257 | United |
| Las Vegas, NV → Raleigh/Durham, NC | 668 | $314 | Delta |
| Raleigh/Durham, NC → San Francisco, CA (Metropolitan Area) | 653 | $374 | United |
| Houston, TX → Raleigh/Durham, NC | 608 | $269 | United |
| Philadelphia, PA → Raleigh/Durham, NC | 577 | $244 | American |
| Nashville, TN → Raleigh/Durham, NC | 538 | $240 | Southwest |
| Phoenix, AZ → Raleigh/Durham, NC | 505 | $327 | American |
| Austin, TX → Raleigh/Durham, NC | 417 | $278 | Delta |
| Raleigh/Durham, NC → Seattle, WA | 380 | $287 | Alaska |
| Detroit, MI → Raleigh/Durham, NC | 367 | $248 | Delta |
| New Orleans, LA → Raleigh/Durham, NC | 334 | $203 | Breeze |
| Raleigh/Durham, NC → San Diego, CA | 314 | $329 | American |
| Raleigh/Durham, NC → Salt Lake City, UT | 293 | $391 | Delta |
| Minneapolis/St. Paul, MN → Raleigh/Durham, NC | 286 | $346 | Delta |
| Fort Myers, FL → Raleigh/Durham, NC | 245 | $213 | Breeze |
| Raleigh/Durham, NC → West Palm Beach/Palm Beach, FL | 244 | $172 | Breeze |
| Pittsburgh, PA → Raleigh/Durham, NC | 226 | $238 | American |
| Raleigh/Durham, NC → St. Louis, MO | 224 | $269 | Southwest |
| Indianapolis, IN → Raleigh/Durham, NC | 220 | $284 | Delta |