| Orlando, FL → Pittsburgh, PA | 1483 | $215 | Southwest |
| New York City, NY (Metropolitan Area) → Pittsburgh, PA | 1347 | $169 | Delta |
| Miami, FL (Metropolitan Area) → Pittsburgh, PA | 1235 | $204 | Southwest |
| Pittsburgh, PA → Tampa, FL (Metropolitan Area) | 708 | $224 | Southwest |
| Boston, MA (Metropolitan Area) → Pittsburgh, PA | 628 | $196 | Delta |
| Dallas/Fort Worth, TX → Pittsburgh, PA | 584 | $282 | American |
| Chicago, IL → Pittsburgh, PA | 558 | $239 | United |
| Las Vegas, NV → Pittsburgh, PA | 546 | $323 | Southwest |
| Los Angeles, CA (Metropolitan Area) → Pittsburgh, PA | 537 | $319 | American |
| Fort Myers, FL → Pittsburgh, PA | 510 | $263 | Southwest |
| Atlanta, GA (Metropolitan Area) → Pittsburgh, PA | 510 | $280 | Delta |
| Houston, TX → Pittsburgh, PA | 455 | $343 | United |
| Phoenix, AZ → Pittsburgh, PA | 447 | $325 | Southwest |
| Denver, CO → Pittsburgh, PA | 374 | $323 | United |
| Pittsburgh, PA → San Francisco, CA (Metropolitan Area) | 369 | $337 | United |
| Pittsburgh, PA → Sarasota/Bradenton, FL | 358 | $208 | Southwest |
| Pittsburgh, PA → Washington, DC (Metropolitan Area) | 310 | $236 | American |
| Nashville, TN → Pittsburgh, PA | 266 | $254 | Southwest |
| Pittsburgh, PA → Raleigh/Durham, NC | 226 | $238 | American |
| Austin, TX → Pittsburgh, PA | 217 | $257 | Southwest |
| Pittsburgh, PA → Seattle, WA | 210 | $247 | Alaska |