| Indianapolis, IN → Orlando, FL | 1518 | $219 | Southwest |
| Indianapolis, IN → Miami, FL (Metropolitan Area) | 1460 | $256 | Southwest |
| Indianapolis, IN → New York City, NY (Metropolitan Area) | 1311 | $218 | Delta |
| Indianapolis, IN → Tampa, FL (Metropolitan Area) | 868 | $224 | Southwest |
| Indianapolis, IN → Washington, DC (Metropolitan Area) | 833 | $244 | American |
| Indianapolis, IN → Los Angeles, CA (Metropolitan Area) | 806 | $353 | American |
| Fort Myers, FL → Indianapolis, IN | 787 | $283 | Southwest |
| Indianapolis, IN → Phoenix, AZ | 743 | $328 | Southwest |
| Indianapolis, IN → Las Vegas, NV | 727 | $287 | Southwest |
| Dallas/Fort Worth, TX → Indianapolis, IN | 721 | $285 | American |
| Atlanta, GA (Metropolitan Area) → Indianapolis, IN | 669 | $301 | Delta |
| Denver, CO → Indianapolis, IN | 669 | $242 | Southwest |
| Houston, TX → Indianapolis, IN | 460 | $310 | United |
| Boston, MA (Metropolitan Area) → Indianapolis, IN | 414 | $331 | Delta |
| Indianapolis, IN → San Francisco, CA (Metropolitan Area) | 413 | $324 | United |
| Indianapolis, IN → Sarasota/Bradenton, FL | 376 | $212 | Southwest |
| Austin, TX → Indianapolis, IN | 319 | $250 | Southwest |
| Indianapolis, IN → San Diego, CA | 309 | $289 | Southwest |
| Indianapolis, IN → Seattle, WA | 277 | $262 | Alaska |
| Indianapolis, IN → Philadelphia, PA | 276 | $364 | American |
| Indianapolis, IN → Minneapolis/St. Paul, MN | 274 | $382 | Delta |
| Charlotte, NC → Indianapolis, IN | 261 | $360 | American |
| Indianapolis, IN → Punta Gorda, FL | 240 | $151 | Allegiant |
| Indianapolis, IN → Raleigh/Durham, NC | 220 | $284 | Delta |