| Houston, TX → New York City, NY (Metropolitan Area) | 3999 | $274 | United |
| Houston, TX → Los Angeles, CA (Metropolitan Area) | 3643 | $261 | United |
| Chicago, IL → Houston, TX | 2646 | $217 | United |
| Houston, TX → Orlando, FL | 2422 | $221 | United |
| Denver, CO → Houston, TX | 2403 | $228 | United |
| Houston, TX → Washington, DC (Metropolitan Area) | 2396 | $275 | United |
| Houston, TX → Miami, FL (Metropolitan Area) | 2390 | $227 | United |
| Atlanta, GA (Metropolitan Area) → Houston, TX | 2352 | $217 | Delta |
| Houston, TX → Las Vegas, NV | 2310 | $256 | United |
| Houston, TX → Phoenix, AZ | 1704 | $247 | United |
| Dallas/Fort Worth, TX → Houston, TX | 1680 | $235 | Southwest |
| Houston, TX → San Francisco, CA (Metropolitan Area) | 1641 | $337 | United |
| Boston, MA (Metropolitan Area) → Houston, TX | 1139 | $290 | United |
| Detroit, MI → Houston, TX | 1080 | $229 | Delta |
| Houston, TX → Philadelphia, PA | 963 | $266 | United |
| Houston, TX → New Orleans, LA | 925 | $254 | United |
| Houston, TX → Nashville, TN | 897 | $287 | Southwest |
| Charlotte, NC → Houston, TX | 886 | $235 | American |
| Houston, TX → Tampa, FL (Metropolitan Area) | 872 | $261 | United |
| Houston, TX → Seattle, WA | 858 | $300 | Alaska |
| Houston, TX → Salt Lake City, UT | 849 | $352 | United |
| Houston, TX → San Diego, CA | 814 | $343 | United |
| Houston, TX → Minneapolis/St. Paul, MN | 747 | $285 | Delta |
| Houston, TX → Midland/Odessa, TX | 637 | $313 | United |
| Houston, TX → Raleigh/Durham, NC | 608 | $269 | United |
| Houston, TX → St. Louis, MO | 604 | $291 | Southwest |
| Houston, TX → Kansas City, MO | 570 | $290 | Southwest |
| El Paso, TX → Houston, TX | 467 | $266 | Southwest |
| Cleveland, OH (Metropolitan Area) → Houston, TX | 461 | $276 | United |
| Houston, TX → Oklahoma City, OK | 460 | $265 | United |
| Houston, TX → Indianapolis, IN | 460 | $310 | United |
| Houston, TX → Portland, OR | 455 | $273 | United |
| Houston, TX → Pittsburgh, PA | 455 | $343 | United |
| Houston, TX → Tulsa, OK | 404 | $269 | United |
| Cincinnati, OH → Houston, TX | 394 | $265 | United |
| Houston, TX → Memphis, TN | 388 | $247 | United |
| Columbus, OH → Houston, TX | 371 | $335 | United |
| Houston, TX → Sacramento, CA | 370 | $355 | United |
| Houston, TX → Jacksonville, FL | 334 | $302 | United |
| Albuquerque, NM → Houston, TX | 327 | $305 | Southwest |
| Fort Myers, FL → Houston, TX | 319 | $257 | United |
| Birmingham, AL → Houston, TX | 286 | $299 | United |
| Houston, TX → Richmond, VA | 260 | $305 | United |
| Houston, TX → Omaha, NE | 252 | $314 | United |
| Houston, TX → West Palm Beach/Palm Beach, FL | 251 | $311 | United |
| Houston, TX → Norfolk, VA (Metropolitan Area) | 249 | $293 | United |
| Houston, TX → Milwaukee, WI | 247 | $273 | United |
| Houston, TX → Lubbock, TX | 241 | $246 | United |
| Harlingen/San Benito, TX → Houston, TX | 229 | $182 | Southwest |
| Houston, TX → Louisville, KY | 223 | $309 | United |
| Charleston, SC → Houston, TX | 215 | $323 | United |
| Houston, TX → Knoxville, TN | 213 | $279 | United |