| Fort Myers, FL → New York City, NY (Metropolitan Area) | 3484 | $251 | United |
| Chicago, IL → Fort Myers, FL | 3144 | $259 | United |
| Boston, MA (Metropolitan Area) → Fort Myers, FL | 2478 | $248 | JetBlue |
| Fort Myers, FL → Minneapolis/St. Paul, MN | 2393 | $287 | Delta |
| Detroit, MI → Fort Myers, FL | 2034 | $267 | Delta |
| Cleveland, OH (Metropolitan Area) → Fort Myers, FL | 1262 | $210 | Frontier |
| Fort Myers, FL → Washington, DC (Metropolitan Area) | 1256 | $290 | Southwest |
| Fort Myers, FL → Philadelphia, PA | 1092 | $266 | American |
| Fort Myers, FL → Indianapolis, IN | 787 | $283 | Southwest |
| Cincinnati, OH → Fort Myers, FL | 733 | $215 | Frontier |
| Columbus, OH → Fort Myers, FL | 655 | $268 | Southwest |
| Denver, CO → Fort Myers, FL | 616 | $337 | United |
| Fort Myers, FL → Milwaukee, WI | 615 | $270 | Southwest |
| Fort Myers, FL → Hartford, CT | 550 | $208 | JetBlue |
| Atlanta, GA (Metropolitan Area) → Fort Myers, FL | 532 | $284 | Delta |
| Fort Myers, FL → Pittsburgh, PA | 510 | $263 | Southwest |
| Fort Myers, FL → St. Louis, MO | 508 | $316 | Southwest |
| Dallas/Fort Worth, TX → Fort Myers, FL | 503 | $327 | American |
| Fort Myers, FL → Nashville, TN | 341 | $304 | Southwest |
| Fort Myers, FL → Houston, TX | 319 | $257 | United |
| Fort Myers, FL → Los Angeles, CA (Metropolitan Area) | 301 | $412 | United |
| Fort Myers, FL → Phoenix, AZ | 297 | $368 | American |
| Fort Myers, FL → Madison, WI | 292 | $225 | Sun Country |
| Charlotte, NC → Fort Myers, FL | 286 | $327 | American |
| Fort Myers, FL → Kansas City, MO | 272 | $333 | Southwest |
| Atlantic City, NJ → Fort Myers, FL | 268 | $108 | Spirit |
| Fort Myers, FL → Las Vegas, NV | 260 | $372 | Breeze |
| Fort Myers, FL → New Haven, CT | 257 | $128 | XP |
| Buffalo, NY → Fort Myers, FL | 253 | $265 | Southwest |
| Fort Myers, FL → Raleigh/Durham, NC | 245 | $213 | Breeze |