| Detroit, MI → Miami, FL (Metropolitan Area) | 3588 | $240 | Delta |
| Detroit, MI → Orlando, FL | 3290 | $231 | Delta |
| Detroit, MI → New York City, NY (Metropolitan Area) | 2559 | $188 | Delta |
| Detroit, MI → Fort Myers, FL | 2034 | $267 | Delta |
| Detroit, MI → Tampa, FL (Metropolitan Area) | 2006 | $216 | Delta |
| Detroit, MI → Las Vegas, NV | 1558 | $317 | Delta |
| Detroit, MI → Los Angeles, CA (Metropolitan Area) | 1481 | $381 | Delta |
| Detroit, MI → Phoenix, AZ | 1473 | $319 | Delta |
| Atlanta, GA (Metropolitan Area) → Detroit, MI | 1350 | $229 | Delta |
| Detroit, MI → Washington, DC (Metropolitan Area) | 1331 | $230 | Delta |
| Dallas/Fort Worth, TX → Detroit, MI | 1178 | $310 | Delta |
| Detroit, MI → Houston, TX | 1080 | $229 | Delta |
| Denver, CO → Detroit, MI | 954 | $239 | Delta |
| Boston, MA (Metropolitan Area) → Detroit, MI | 848 | $258 | Delta |
| Detroit, MI → San Francisco, CA (Metropolitan Area) | 803 | $426 | Delta |
| Chicago, IL → Detroit, MI | 735 | $265 | Delta |
| Charlotte, NC → Detroit, MI | 568 | $262 | Delta |
| Detroit, MI → Nashville, TN | 524 | $286 | Delta |
| Detroit, MI → Philadelphia, PA | 503 | $273 | Delta |
| Detroit, MI → San Diego, CA | 499 | $427 | Delta |
| Detroit, MI → New Orleans, LA | 477 | $242 | Delta |
| Detroit, MI → Seattle, WA | 466 | $287 | Delta |
| Detroit, MI → West Palm Beach/Palm Beach, FL | 455 | $326 | Delta |
| Detroit, MI → Minneapolis/St. Paul, MN | 439 | $379 | Delta |
| Austin, TX → Detroit, MI | 405 | $361 | Delta |
| Detroit, MI → Raleigh/Durham, NC | 367 | $248 | Delta |
| Detroit, MI → Salt Lake City, UT | 300 | $474 | Delta |
| Detroit, MI → St. Louis, MO | 286 | $307 | Delta |
| Detroit, MI → San Antonio, TX | 284 | $366 | Delta |
| Detroit, MI → Jacksonville, FL | 268 | $318 | Delta |
| Detroit, MI → Kansas City, MO | 258 | $385 | Delta |
| Detroit, MI → Sarasota/Bradenton, FL | 240 | $350 | Delta |