| Columbus, OH → Orlando, FL | 1294 | $227 | Southwest |
| Columbus, OH → New York City, NY (Metropolitan Area) | 1240 | $234 | Delta |
| Columbus, OH → Miami, FL (Metropolitan Area) | 1181 | $230 | Southwest |
| Columbus, OH → Fort Myers, FL | 655 | $268 | Southwest |
| Columbus, OH → Washington, DC (Metropolitan Area) | 629 | $230 | American |
| Chicago, IL → Columbus, OH | 628 | $248 | United |
| Columbus, OH → Tampa, FL (Metropolitan Area) | 619 | $234 | Southwest |
| Columbus, OH → Los Angeles, CA (Metropolitan Area) | 615 | $308 | American |
| Columbus, OH → Dallas/Fort Worth, TX | 582 | $306 | American |
| Atlanta, GA (Metropolitan Area) → Columbus, OH | 565 | $241 | Delta |
| Columbus, OH → Las Vegas, NV | 550 | $322 | Southwest |
| Columbus, OH → Phoenix, AZ | 547 | $343 | American |
| Boston, MA (Metropolitan Area) → Columbus, OH | 433 | $281 | Delta |
| Columbus, OH → Denver, CO | 408 | $277 | United |
| Columbus, OH → Houston, TX | 371 | $335 | United |
| Columbus, OH → Sarasota/Bradenton, FL | 329 | $224 | Southwest |
| Columbus, OH → San Francisco, CA (Metropolitan Area) | 290 | $341 | Southwest |
| Columbus, OH → San Diego, CA | 259 | $271 | Southwest |
| Austin, TX → Columbus, OH | 236 | $252 | Southwest |
| Columbus, OH → Philadelphia, PA | 232 | $352 | American |
| Columbus, OH → Minneapolis/St. Paul, MN | 224 | $370 | Delta |
| Columbus, OH → Seattle, WA | 220 | $250 | Alaska |