| Cleveland, OH (Metropolitan Area) → Orlando, FL | 1953 | $178 | Frontier |
| Cleveland, OH (Metropolitan Area) → Miami, FL (Metropolitan Area) | 1651 | $204 | Frontier |
| Cleveland, OH (Metropolitan Area) → Fort Myers, FL | 1262 | $210 | Frontier |
| Cleveland, OH (Metropolitan Area) → New York City, NY (Metropolitan Area) | 1249 | $187 | United |
| Cleveland, OH (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 1095 | $161 | Frontier |
| Cleveland, OH (Metropolitan Area) → Las Vegas, NV | 872 | $239 | Frontier |
| Cleveland, OH (Metropolitan Area) → Phoenix, AZ | 763 | $272 | Frontier |
| Chicago, IL → Cleveland, OH (Metropolitan Area) | 725 | $225 | United |
| Atlanta, GA (Metropolitan Area) → Cleveland, OH (Metropolitan Area) | 700 | $223 | Delta |
| Cleveland, OH (Metropolitan Area) → Los Angeles, CA (Metropolitan Area) | 662 | $334 | United |
| Cleveland, OH (Metropolitan Area) → Dallas/Fort Worth, TX | 557 | $316 | American |
| Cleveland, OH (Metropolitan Area) → Denver, CO | 504 | $243 | United |
| Cleveland, OH (Metropolitan Area) → Washington, DC (Metropolitan Area) | 491 | $243 | American |
| Boston, MA (Metropolitan Area) → Cleveland, OH (Metropolitan Area) | 475 | $220 | Delta |
| Cleveland, OH (Metropolitan Area) → Houston, TX | 461 | $276 | United |
| Cleveland, OH (Metropolitan Area) → Sarasota/Bradenton, FL | 455 | $150 | Frontier |
| Cleveland, OH (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 335 | $351 | United |
| Cleveland, OH (Metropolitan Area) → Nashville, TN | 281 | $252 | Southwest |
| Charlotte, NC → Cleveland, OH (Metropolitan Area) | 258 | $335 | American |
| Cleveland, OH (Metropolitan Area) → Minneapolis/St. Paul, MN | 215 | $395 | Delta |
| Cleveland, OH (Metropolitan Area) → Seattle, WA | 212 | $251 | Alaska |