| Boston, MA (Metropolitan Area) → Orlando, FL | 4936 | $208 | JetBlue |
| Boston, MA (Metropolitan Area) → Miami, FL (Metropolitan Area) | 4795 | $241 | JetBlue |
| Boston, MA (Metropolitan Area) → Washington, DC (Metropolitan Area) | 4418 | $192 | American |
| Boston, MA (Metropolitan Area) → Los Angeles, CA (Metropolitan Area) | 2828 | $342 | JetBlue |
| Boston, MA (Metropolitan Area) → New York City, NY (Metropolitan Area) | 2718 | $222 | Delta |
| Boston, MA (Metropolitan Area) → Chicago, IL | 2707 | $178 | United |
| Boston, MA (Metropolitan Area) → Fort Myers, FL | 2478 | $248 | JetBlue |
| Boston, MA (Metropolitan Area) → San Francisco, CA (Metropolitan Area) | 2461 | $407 | United |
| Boston, MA (Metropolitan Area) → Tampa, FL (Metropolitan Area) | 2330 | $237 | Delta |
| Atlanta, GA (Metropolitan Area) → Boston, MA (Metropolitan Area) | 1882 | $278 | Delta |
| Boston, MA (Metropolitan Area) → West Palm Beach/Palm Beach, FL | 1787 | $254 | JetBlue |
| Boston, MA (Metropolitan Area) → Dallas/Fort Worth, TX | 1668 | $286 | American |
| Boston, MA (Metropolitan Area) → Denver, CO | 1618 | $248 | United |
| Boston, MA (Metropolitan Area) → Phoenix, AZ | 1481 | $293 | American |
| Boston, MA (Metropolitan Area) → Philadelphia, PA | 1478 | $194 | American |
| Boston, MA (Metropolitan Area) → Las Vegas, NV | 1362 | $340 | JetBlue |
| Boston, MA (Metropolitan Area) → Raleigh/Durham, NC | 1296 | $190 | Delta |
| Boston, MA (Metropolitan Area) → San Diego, CA | 1168 | $320 | JetBlue |
| Boston, MA (Metropolitan Area) → Houston, TX | 1139 | $290 | United |
| Boston, MA (Metropolitan Area) → Nashville, TN | 1006 | $221 | Southwest |
| Austin, TX → Boston, MA (Metropolitan Area) | 987 | $269 | Delta |
| Boston, MA (Metropolitan Area) → Charlotte, NC | 957 | $295 | American |
| Boston, MA (Metropolitan Area) → Seattle, WA | 905 | $325 | Delta |
| Boston, MA (Metropolitan Area) → Detroit, MI | 848 | $258 | Delta |
| Boston, MA (Metropolitan Area) → Salt Lake City, UT | 814 | $426 | Delta |
| Boston, MA (Metropolitan Area) → Sarasota/Bradenton, FL | 787 | $247 | JetBlue |
| Boston, MA (Metropolitan Area) → Jacksonville, FL | 754 | $215 | Delta |
| Boston, MA (Metropolitan Area) → New Orleans, LA | 692 | $246 | Delta |
| Boston, MA (Metropolitan Area) → Minneapolis/St. Paul, MN | 661 | $377 | Delta |
| Boston, MA (Metropolitan Area) → Charleston, SC | 652 | $198 | Delta |
| Boston, MA (Metropolitan Area) → Pittsburgh, PA | 628 | $196 | Delta |
| Boston, MA (Metropolitan Area) → Richmond, VA | 475 | $195 | JetBlue |
| Boston, MA (Metropolitan Area) → Cleveland, OH (Metropolitan Area) | 475 | $220 | Delta |
| Boston, MA (Metropolitan Area) → Savannah, GA | 457 | $212 | JetBlue |
| Boston, MA (Metropolitan Area) → Columbus, OH | 433 | $281 | Delta |
| Boston, MA (Metropolitan Area) → Indianapolis, IN | 414 | $331 | Delta |
| Boston, MA (Metropolitan Area) → St. Louis, MO | 394 | $326 | Southwest |
| Boston, MA (Metropolitan Area) → Cincinnati, OH | 393 | $317 | Delta |
| Boston, MA (Metropolitan Area) → Portland, OR | 375 | $318 | Alaska |
| Boston, MA (Metropolitan Area) → Myrtle Beach, SC | 371 | $150 | Spirit |
| Boston, MA (Metropolitan Area) → San Antonio, TX | 315 | $334 | Delta |
| Boston, MA (Metropolitan Area) → Norfolk, VA (Metropolitan Area) | 304 | $211 | American |
| Boston, MA (Metropolitan Area) → Vero Beach, FL | 285 | $184 | JetBlue |
| Boston, MA (Metropolitan Area) → Buffalo, NY | 270 | $156 | JetBlue |
| Boston, MA (Metropolitan Area) → Key West, FL | 261 | $313 | JetBlue |
| Boston, MA (Metropolitan Area) → Kansas City, MO | 261 | $377 | Delta |
| Boston, MA (Metropolitan Area) → Daytona Beach, FL | 242 | $175 | JetBlue |
| Boston, MA (Metropolitan Area) → Bozeman, MT | 213 | $361 | JetBlue |